The VSPGx module provides precise star allele calling, CPIC/FDA-guided drug–gene interaction interpretation, and comprehensive clinical reporting for precision dosing and ADR reduction.
Amitriptyline: Avoid use due to risk of sub-therapeutic response or toxicity. Consider alternative medication.
VSPGx automates the translation of genotypes into star allele nomenclature and clinical phenotypes, providing labs with a validated pathway to pharmacogenomic reporting.
Automate the mapping of SNVs, indels, and structural variants to standardized star allele nomenclature. Support for complex genes like CYP2D6, including copy number events.
Native integration with CPIC and FDA guidelines. Automatically map diplotypes to phenotypes and surface evidence-based prescribing recommendations.
Generate laboratory-branded PGx reports including current medications, major gene-drug interactions, and drug-specific dosing guidance in an oncologist-ready format.
Our structured algorithm ensures reproducible results across any genomic dataset, from targeted panels to whole genomes.
Identify variants at CPIC-specified positions and map them to standardized star allele nomenclature (e.g., CYP2C19 *2, *17).
Pair identified alleles per gene to assign diplotypes. Calculate activity scores and map to metabolizer phenotypes (e.g., Poor, Normal, Ultra-Rapid).
Automatically match phenotypes to CPIC and FDA prescribing recommendations. Filter guidance based on patient-specific medications.
VSPGx is designed for clinical flexibility, supporting any assay type that provides genotype data. No specialized PGx-only sequencing is required.
Process VCF inputs from targeted gene panels, clinical exomes, and whole genomes, as well as microarray-derived genotypes.
Incorporate copy-number events (e.g., CYP2D6 *1xN duplications or *5 deletions) directly into phenotype determination.
Scale your PGx operations with VSPipeline and VSWarehouse integration, enabling end-to-end automated pipelines from raw data to report.
Precision dosing for opioids like codeine and tramadol. Avoid toxicity in Ultra-Rapid metabolizers and sub-therapeutic response in Poor metabolizers.
Clopidogrel (Plavix) therapy guidance. Identify patients with reduced activation risk to prevent thrombotic events.
Reduce the risk of statin-induced myopathy through genotype-informed dosing and alternative medication selection.
Request a personalized evaluation with your own pharmacogenomics data.
Deep dives into star allele calling methodologies, CPIC implementation, and clinical PGx workflows.
Join leading clinical centers worldwide using VSPGx for precision star allele calling and guideline-driven interpretation.