Access the world's most trusted genomic knowledge bases directly within the VarSeq Suite. Our premium annotation add-ons integrate expertly curated data from Golden Helix CancerKB, OMIM, LOVD, CADD, and others into a unified analysis environment.
High-quality genomic analysis is only as strong as the data that powers it. While public databases provide an essential starting point, clinical-grade workflows often require the depth and precision of expert-curated, licensed databases. Golden Helix provides a seamless way to incorporate these premium sources into your analysis, ensuring that your reports are backed by the most current and comprehensive evidence available.
All databases are cleaned, standardized, and integrated for immediate use within VarSeq.
Stay current with evolving genomic knowledge through our automated monthly dataset updates.
Ensures reproducibility and compliance by storing all annotation data locally on your infrastructure.
Our flagship expert-curated database, Golden Helix CancerKB, provides diagnostic, prognostic, and therapeutic interpretations based on the latest NCCN and WHO guidelines. Specifically designed for oncology workflows, it offers a comprehensive overhaul of somatic variant interpretations, including hematological cancers.
Overhaul of diagnostic and prognostic interpretations for hematological cancers.
Integration of the latest NCCN and WHO guideline updates.
Automated identification and classification of somatic mutations in VSClinical.
We partner with industry leaders to provide direct licensing and integration for the databases that define modern clinical genetics.
The Leiden Open Variation Database is a federated network of expert-curated Locus-Specific Databases (LSDBs), providing deep clinical and functional insights often missing from larger repositories.
Online Mendelian Inheritance in Man provides comprehensive, curated summaries of gene-phenotype relationships and genetic disorders.
Combined Annotation Dependent Depletion (CADD) is a tool for scoring the deleteriousness of single nucleotide variants as well as insertion/deletion variants in the human genome.
Golden Helix maintains an extensive catalog of public and premium datasets, all vetted, cleaned, and optimized for the Golden Helix high-performance annotation engine.
Showing selected annotations from our catalog of 200+ sources
Premium annotations like OMIM, Mastermind Curated Variants, and CancerKB are licensed as annual add-ons to your VarSeq subscription. Golden Helix handles the technical integration, data cleaning, and updates, providing you with a single point of contact for both the analysis software and the curated data sources.
Golden Helix provides monthly updates for all curated datasets. This ensures that you have access to the latest versions of public databases (like ClinVar and gnomAD) and the most recent releases of professional sources like OMIM and Mastermind, all vetted and standardized for our platform.
Yes. All annotation data is stored locally on your analysis workstation or server. This is a core requirement for many clinical labs to ensure reproducibility, data privacy, and performance independent of external service availability or cloud dependencies.
Learn how premium annotations enhance clinical variant interpretation and reporting workflows.
Talk to our team about integrating premium clinical databases into your workflow.